Table

The Costanzi Research Group

Experimentally solved GPCR structures
(Updated January 17, 2020)

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Row PDB ID Family Receptor Organism Res. (Ang.) Putative State Ligand Ligand
chemical class
Ligand
pharmacological
class
Signaling partner Antibody Fusion protein Method Year References
14JKVFrizzledSmoothenedHuman2.45inactiveLY2940680small moleculeantagonistNANABRIL-NTX-RAY2013Wang et al. 2013
24N4WFrizzledSmoothenedHuman2.8inactiveSANT-1small moleculeantagonistNANABRIL-NTX-RAY2014Wang et al. 2014
34O9RFrizzledSmoothenedHuman3.2inactiveCyclopaminesmall moleculeantagonistNANABRIL-NTX-RAY2014Weierstall et al. 2014
44QIMFrizzledSmoothenedHuman2.61inactiveANTA XVsmall moleculeantagonistNANABRIL-IL3X-RAY2014Wang et al. 2014
54QINFrizzledSmoothenedHuman2.6inactive or minimally activatedSAG1.5small moleculeagonistNANABRIL-IL3X-RAY2014Wang et al. 2014
65L7DFrizzledSmoothenedHuman3.2inactive or minimally activatedCholesterolsmall moleculeagonist (allosteric, bound to extracellular CRD)NANABRIL-IL3X-RAY2016Byrne et al. 2016
75L7IFrizzledSmoothenedHuman3.3inactiveVismodegibsmall moleculeantagonistNANABRIL-IL3X-RAY2016Byrne et al. 2016
84K5YSecretinCRF1 corticotropin-releasing factor receptorHuman2.98inactiveCP-376395small moleculeantagonist (negative allosteric modulator)NANANAX-RAY2013Hollenstein et al. 2013
94L6RSecretinGlucagon receptorHuman3.3inactiveunligandedunligandedunligandedNANABRIL-NTX-RAY2013Siu et al. 2013
104Z9GSecretinCRF1 corticotropin-releasing factor receptorHuman3.18inactiveCP-376395small moleculeantagonist (allosteric)NANATBDX-RAY2016Dore et al. 2016
115EE7SecretinGlucagon receptorHuman2.5inactiveMK-0893small moleculeantagonist (allosteric)NANAT4L-IL2X-RAY2016Jazayeri et al. 2016
121F88RhodopsinRhodopsinBovine2.8inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2000Palczewski et al. 2000
131GZMRhodopsinRhodopsinBovine2.65inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2003Li et al. 2003
141HZXRhodopsinRhodopsinBovine2.8inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2001Teller et al. 2001
151L9HRhodopsinRhodopsinBovine2.6inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2002Okada et al. 2002
161U19RhodopsinRhodopsinBovine2.2inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2004Okada et al. 2004
172G87RhodopsinRhodopsinBovine2.6inactive or minimally activated (bathorhodopsin)all-trans-retinal (distorted)small moleculeagonistNANANAX-RAY2006Nakamichi et al. 2006
182HPYRhodopsinRhodopsinBovine2.8inactive or minimally activated (lumirhodopsin)all-trans-retinalsmall moleculeagonistNANANAX-RAY2006Nakamichi et al. 2006
192I35RhodopsinRhodopsinBovine3.8inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2006Salom et al. 2006
202I36RhodopsinRhodopsinBovine4.1inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2006Salom et al. 2006
212I37RhodopsinRhodopsinBovine4.15inactive or minimally activated (early photoactivation intermediate)all-trans-retinalsmall moleculeagonistNANANAX-RAY2006Salom et al. 2006
222J4YRhodopsinRhodopsinBovine3.4inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2007Standfuss et al. 2007
232PEDRhodopsinRhodopsinBovine2.95inactive9-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2007Nakamichi et al. 2007
242R4RRhodopsinbeta2 adrenergic receptorHuman3.4inactivecarazololsmall moleculeinverse agonistNAFab (intracellular)NAX-RAY2007Rasmussen et al. 2007
252R4SRhodopsinbeta2 adrenergic receptorHuman3.4inactivecarazololsmall moleculeinverse agonistNAFab (intracellular)NAX-RAY2007Rasmussen et al. 2007
262RH1Rhodopsinbeta2 adrenergic receptorHuman2.4inactivecarazololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2007Cherezov et al. 2007
272VT4Rhodopsinbeta1 adrenergic receptorTurkey2.7inactivecyanopindololsmall moleculeantagonistNANANAX-RAY2008Warne et al. 2008
282X72RhodopsinRhodopsinBovine3.0activatedall-trans-retinalsmall moleculeagonistGt peptide (fused)NANAX-RAY2011Standfuss et al. 2011
292Y00Rhodopsinbeta1 adrenergic receptorTurkey2.5inactive or minimally activateddobutaminesmall moleculepartial agonistNANANAX-RAY2011Warne et al. 2011
302Y01Rhodopsinbeta1 adrenergic receptorTurkey2.6inactive or minimally activateddobutaminesmall moleculepartial agonistNANANAX-RAY2011Warne et al. 2011
312Y02Rhodopsinbeta1 adrenergic receptorTurkey2.6inactive or minimally activatedcarmoterolsmall moleculeagonistNANANAX-RAY2011Warne et al. 2011
322Y03Rhodopsinbeta1 adrenergic receptorTurkey2.85inactive or minimally activatedisoprenalinesmall moleculeagonistNANANAX-RAY2011Warne et al. 2011
332Y04Rhodopsinbeta1 adrenergic receptorTurkey3.05inactive or minimally activatedsalbutamolsmall moleculepartial agonistNANANAX-RAY2011Warne et al. 2011
342YCWRhodopsinbeta1 adrenergic receptorTurkey3.0inactivecarazololsmall moleculeantagonistNANANAX-RAY2011Moukhametzianov et al. 2011
352YCXRhodopsinbeta1 adrenergic receptorTurkey3.25inactivecyanopindololsmall moleculeantagonistNANANAX-RAY2011Moukhametzianov et al. 2011
362YCYRhodopsinbeta1 adrenergic receptorTurkey3.15inactivecyanopindololsmall moleculeantagonistNANANAX-RAY2011Moukhametzianov et al. 2011
372YCZRhodopsinbeta1 adrenergic receptorTurkey3.65inactiveiodocyanopindololsmall moleculeantagonistNANANAX-RAY2011Moukhametzianov et al. 2011
382YDORhodopsinA2A adenosine receptorHuman3.0inactive or minimally activatedadenosinesmall moleculeagonistNANANAX-RAY2011Lebon et al. 2011
392YDVRhodopsinA2A adenosine receptorHuman2.6inactive or minimally activatedNECAsmall moleculeagonistNANANAX-RAY2011Lebon et al. 2011
402Z73RhodopsinRhodopsinSquid2.5inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2008Murakami et al. 2008
412ZIYRhodopsinRhodopsinSquid3.7inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2008Shimamura et al. 2008
423AYMRhodopsinRhodopsinSquid2.8inactive or minimally activated (bathorhodopsin)all-trans-retinalsmall moleculeagonistNANANAX-RAY2011Murakami et al. 2011
433AYNRhodopsinRhodopsinSquid2.7inactive9-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2011Murakami et al. 2011
443C9LRhodopsinRhodopsinBovine2.65inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2008Stenkamp et al. 2008
453C9MRhodopsinRhodopsinBovine3.4inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2008Stenkamp et al. 2008
463CAPRhodopsinRhodopsinBovine2.9activatedunligandedunligandedunligandedNANANAX-RAY2008Park et al. 2008
473D4SRhodopsinbeta2 adrenergic receptorHuman2.8inactivetimololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2008Hanson et al. 2008
483DQBRhodopsinRhodopsinBovine3.2activatedunligandedunligandedunligandedGt peptide (fused)NANAX-RAY2008Scheerer et al. 2008
493EMLRhodopsinA2A adenosine receptorHuman2.6inactiveZM-241385small moleculeantagonistNANAT4L-IL3X-RAY2008Jaakola et al. 2008
503KJ6Rhodopsinbeta2 adrenergic receptorHuman3.4inactivecarazololsmall moleculeinverse agonistNAFab (intracellular)NAX-RAY2010Bokoch et al. 2010
513NY8Rhodopsinbeta2 adrenergic receptorHuman2.84inactiveICI 118551small moleculeinverse agonistNANAT4L-IL3X-RAY2010Wacker et al. 2010
523NY9Rhodopsinbeta2 adrenergic receptorHuman2.84inactiverecent comp.small moleculeinverse agonistNANAT4L-IL3X-RAY2010Wacker et al. 2010
533NYARhodopsinbeta2 adrenergic receptorHuman3.16inactivealprenololsmall moleculeantagonistNANAT4L-IL3X-RAY2010Wacker et al. 2010
543OAXRhodopsinRhodopsinBovine2.6inactive11-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2011Makino et al. 2011
553ODURhodopsinCXCR4 chemokine receptorHuman2.5inactiveIT1tsmall moleculeantagonistNANAT4L-IL3X-RAY2010Wu et al. 2010
563OE0RhodopsinCXCR4 chemokine receptorHuman2.9inactiveCVX15peptideantagonistNANAT4L-IL3X-RAY2010Wu et al. 2010
573OE6RhodopsinCXCR4 chemokine receptorHuman3.2inactiveIT1tsmall moleculeantagonistNANAT4L-IL3X-RAY2010Wu et al. 2010
583OE8RhodopsinCXCR4 chemokine receptorHuman3.1inactiveIT1tsmall moleculeantagonistNANAT4L-IL3X-RAY2010Wu et al. 2010
593OE9RhodopsinCXCR4 chemokine receptorHuman3.1inactiveIT1tsmall moleculeantagonistNANAT4L-IL3X-RAY2010Wu et al. 2010
603P0GRhodopsinbeta2 adrenergic receptorHuman3.5activatedBI-167107small moleculeagonistNANanobody (intracellular)T4L-NTX-RAY2011Rasmussen et al. 2011
613PBLRhodopsinD3 dopamine receptorHuman2.89inactiveEticlopridesmall moleculeantagonistNANAT4L-IL3X-RAY2010Chien et al. 2010
623PDSRhodopsinbeta2 adrenergic receptorHuman3.5inactive or minimally activatedFAUC50small moleculeagonist (irreversible)NANAT4L-IL3X-RAY2011Rosenbaum et al. 2011
633PQRRhodopsinRhodopsinBovine2.85activatedall-trans-retinalsmall moleculeagonistGt peptide (fused)NANAX-RAY2011Choe et al. 2011
643PWHRhodopsinA2A adenosine receptorHuman3.3inactiveZM-241385small moleculeantagonistNANANAX-RAY2011Dore et al. 2011
653PXORhodopsinRhodopsinBovine3.0activatedall-trans-retinalsmall moleculeagonistNANANAX-RAY2011Choe et al. 2011
663QAKRhodopsinA2A adenosine receptorHuman2.71inactive or minimally activatedUK-432097small moleculeagonistNANAT4L-IL3X-RAY2011Xu et al. 2011
673REYRhodopsinA2A adenosine receptorHuman3.31inactiveXACsmall moleculeantagonistNANANAX-RAY2011Dore et al. 2011
683RFMRhodopsinA2A adenosine receptorHuman3.6inactivecaffeinesmall moleculeantagonistNANANAX-RAY2011Dore et al. 2011
693RZERhodopsinH1 histamine receptorHuman3.1inactiveDoxepinsmall moleculeantagonistNANAT4L-IL3X-RAY2011Shimamura et al. 2011
703UZARhodopsinA2A adenosine receptorHuman3.27inactive1 2 4-triazine 4gsmall moleculeantagonistNANANAX-RAY2012Congreve et al. 2012
713UZCRhodopsinA2A adenosine receptorHuman3.34inactive1 2 4-triazine 4gsmall moleculeantagonistNANANAX-RAY2012Congreve et al. 2012
723V2WRhodopsinS1P1 sphingosine 1-phosphate receptorHuman3.35inactiveML056small moleculeantagonistNANAT4L-IL3X-RAY2012Hanson et al. 2012
733V2YRhodopsinS1P1 sphingosine 1-phosphate receptorHuman2.8inactiveML056small moleculeantagonistNANAT4L-IL3X-RAY2012Hanson et al. 2012
743VG9RhodopsinA2A adenosine receptorHuman2.7inactiveZM-241385small moleculeantagonistNAFab (intracellular, allosteric inverse agonist)NAX-RAY2012Hino et al. 2012
753VGARhodopsinA2A adenosine receptorHuman3.1inactiveZM-241385small moleculeantagonistNAFab (intracellular, allosteric inverse agonist)NAX-RAY2012Hino et al. 2012
763VW7RhodopsinPAR1 proteinase-activated receptorHuman2.2inactiveVorapaxarsmall moleculeantagonistNANAT4L-IL3X-RAY2012Zhang et al. 2012
773ZEVRhodopsinNTS1 neurotensin receptorRat3.0inactive or minimally activatedNeurotensin (8-13)peptideagonistNANANAX-RAY2014Egloff et al. 2014
783ZPQRhodopsinbeta1 adrenergic receptorTurkey2.8inactive4-(piperazin-1-yl)-1H-indolesmall moleculeantagonistNANANAX-RAY2013Christopher et al. 2013
793ZPRRhodopsinbeta1 adrenergic receptorTurkey2.7inactive4-methyl-2-(piperazin-1-yl)quinolinesmall moleculeantagonistNANANAX-RAY2013Christopher et al. 2013
804A4MRhodopsinRhodopsinBovine3.3activatedall-trans-retinalsmall moleculeagonistNANANAX-RAY2012Deupi et al. 2012
814AMIRhodopsinbeta1 adrenergic receptorTurkey3.2inactive or minimally activatedbucindololsmall moleculeagonist (biased, beta-arrestin)NANANAX-RAY2012Warne et al. 2012
824AMJRhodopsinbeta1 adrenergic receptorTurkey2.3inactive or minimally activatedcarvedilolsmall moleculeagonist (biased, beta-arrestin)NANANAX-RAY2012Warne et al. 2012
834BEYRhodopsinRhodopsinBovine2.9activatedunligandedunligandedunligandedGt peptide (fused)NANAX-RAY2013Singhal et al. 2013
844BEZRhodopsinRhodopsinBovine3.3activatedunligandedunligandedunligandedNANANAX-RAY2013Singhal et al. 2013
854BUORhodopsinNTS1 neurotensin receptorRat2.75inactive or minimally activatedNeurotensin (8-13)peptideagonistNANANAX-RAY2014Egloff et al. 2014
864BV0RhodopsinNTS1 neurotensin receptorRat3.1inactive or minimally activatedNeurotensin (8-13)peptideagonistNANANAX-RAY2014Egloff et al. 2014
874BVNRhodopsinbeta1 adrenergic receptorTurkey2.1inactivecyanopindololsmall moleculeantagonistNANANAX-RAY2014Miller-Gallacher et al. 2014
884BWBRhodopsinNTS1 neurotensin receptorRat3.57inactive or minimally activatedNeurotensin (8-13)peptideagonistNANANAX-RAY2014Egloff et al. 2014
894DAJRhodopsinM3 muscarinic receptorRat3.4inactiveTiotropiumsmall moleculeinverse agonistNANAT4L-IL3X-RAY2012Kruse et al. 2012
904DJHRhodopsinkappa opioid receptorHuman2.9inactiveJDTicsmall moleculeantagonistNANAT4L-IL3X-RAY2012Wu et al. 2012
914DKLRhodopsinmu opioid receptorMouse2.8inactivefunaltrexaminesmall moleculeantagonist (irreversible)NANAT4L-IL3X-RAY2012Manglik et al. 2012
924EA3RhodopsinNociception-orphanin FQ (NOP) receptorHuman3.01inactivePeptide mimetic c-24small moleculeantagonistNANABRIL-NTX-RAY2012Thompson et al. 2012
934EIYRhodopsinA2A adenosine receptorHuman1.8inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2012Liu et al. 2012
944EJ4Rhodopsindelta opioid receptorMouse3.4inactiveNaltrindolesmall moleculeantagonistNANAT4L-IL3X-RAY2012Granier et al. 2012
954GBRRhodopsinbeta2 adrenergic receptorHuman3.99inactivecarazololsmall moleculeinverse agonistNANAT4L-NTX-RAY2012Zou et al. 2012
964GPORhodopsinbeta1 adrenergic receptorTurkey3.5inactiveunligandedunligandedunligandedNANANAX-RAY2013Huang et al. 2013
974GRVRhodopsinNTS1 neurotensin receptorRat2.8activated (partially)Neurotensin (8-13)peptideagonistNANAT4L-IL3X-RAY2012White et al. 2012
984IAQRhodopsin5-HT1B serotonin receptorHuman2.8inactive or minimally activatedDihydroergotaminesmall moleculeagonistNANABRIL-IL3X-RAY2013Wang et al. 2013
994IARRhodopsin5-HT1B serotonin receptorHuman2.7inactive or minimally activatedErgotaminesmall moleculeagonistNANABRIL-IL3X-RAY2013Wang et al. 2013
1004IB4Rhodopsin5-HT2B serotonin receptorHuman2.7inactive or minimally activatedErgotaminesmall moleculeagonist (biased, beta-arrestin)NANABRIL-IL3X-RAY2013Wacker et al. 2013
1014J4QRhodopsinRhodopsinBovine2.65activatedB-octylglucosideNANAGt peptide (fused)NANAX-RAY2013Park et al. 2013
1024LDERhodopsinbeta2 adrenergic receptorHuman2.79activatedBI-167107small moleculeagonistNANanobody (intracellular)T4L-NTX-RAY2013Ring et al. 2013
1034LDLRhodopsinbeta2 adrenergic receptorHuman3.1activatedHydroxybenzylisoproterenolsmall moleculeagonistNANanobody (intracellular)T4L-NTX-RAY2013Ring et al. 2013
1044LDORhodopsinbeta2 adrenergic receptorHuman3.2activatedAdrenalinesmall moleculeagonistNANanobody (intracellular)T4L-NTX-RAY2013Ring et al. 2013
1054MBSRhodopsinCCR5 chemokine receptorHuman2.71inactiveMaravirocsmall moleculeinverse agonistNANARubredoxin-IL3X-RAY2013Tan et al. 2013
1064MQSRhodopsinM2 muscarinic receptorHuman3.5activatediperoxosmall moleculeagonistNANanobody (intracellular)NAX-RAY2013Kruse et al. 2013
1074MQTRhodopsinM2 muscarinic receptorHuman3.7activatediperoxo + LY2119620small moleculeagonist + positive allosteric modulatorNANanobody (intracellular)NAX-RAY2013Kruse et al. 2013
1084N6HRhodopsindelta opioid receptorHuman1.8inactiveNaltrindolesmall moleculeantagonistNANABRIL-NTX-RAY2013Fenalti et al. 2013
1094NC3Rhodopsin5-HT2B serotonin receptorHuman2.8inactive or minimally activatedErgotaminesmall moleculeagonist (biased, beta-arrestin)NANABRIL-IL3X-RAY2013Liu et al. 2013
1104NTJRhodopsinP2Y12 receptorHuman2.62inactiveAZD1283small moleculeantagonistNANABRIL-IL3X-RAY2014Zhang et al. 2014
1114PHURhodopsinFFA1 receptor (GPR40)Human2.33inactiveTAK-875 or fasiglifamsmall moleculeantagonistNANAT4L-IL3X-RAY2014Srivastava et al. 2014
1124PXFRhodopsinRhodopsinBovine2.75activatedunligandedunligandedunligandedVisual arrestin-1 peptideNANAX-RAY2014Szczepek et al. 2014
1134PXZRhodopsinP2Y12 receptorHuman2.5inactive or minimally activated2-MeSADPsmall moleculeagonistNANABRIL-IL3X-RAY2014Zhang et al. 2014
1144PY0RhodopsinP2Y12 receptorHuman3.1inactive or minimally activated2-MeSADPsmall moleculeagonistNANABRIL-IL3X-RAY2014Zhang et al. 2014
1154QKXRhodopsinbeta2 adrenergic receptorHuman3.3activatedCovalently-bound analog of noradrenalinesmall moleculeagonist (irreversible)NANanobody (intracellular)T4L-NTX-RAY2014Weichert et al. 2014
1164RWARhodopsindelta opioid receptorHuman3.28inactiveH-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2)peptideantagonistNANABRIL-NTX-RAY2015Fenalti et al. 2015
1174RWDRhodopsindelta opioid receptorHuman2.7inactiveH-Dmt-Tic-Phe-Phe-NH2 (DIPP-NH2)peptideantagonistNANABRIL-NTX-RAY2015Fenalti et al. 2015
1184RWSRhodopsinCXCR4 chemokine receptorHuman3.1inactiveViral chemokinepeptideantagonistNANAT4L-IL3X-RAY2015Qin et al. 2015
1194S0VRhodopsinOX2 orexin receptorHuman2.5inactiveSuvorexantsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2015Yin et al. 2015
1204U14RhodopsinM3 muscarinic receptorRat3.57inactiveTiotropiumsmall moleculeinverse agonistNANAdsT4L-IL3X-RAY2014Thorsen et al. 2014
1214U15RhodopsinM3 muscarinic receptorRat2.8inactiveTiotropiumsmall moleculeinverse agonistNANAdsT4L-IL3X-RAY2014Thorsen et al. 2014
1224U16RhodopsinM3 muscarinic receptorRat3.7inactiveN-methyl scopolaminesmall moleculeantagonistNANAdsT4L-IL3X-RAY2014Thorsen et al. 2014
1234UG2RhodopsinA2A adenosine receptorHuman2.6inactive or minimally activatedCGS21680small moleculeagonistNANANAX-RAY2015Lebon et al. 2015
1244UHRRhodopsinA2A adenosine receptorHuman2.6inactive or minimally activatedCGS21680small moleculeagonistNANANAX-RAY2015Lebon et al. 2015
1254WW3RhodopsinRhodopsinSquid2.8inactive or minimally activated (lumirhodopsin)all-trans-retinalsmall moleculeagonistNANANAX-RAY2015Murakami et al. 2015
1264X1HRhodopsinRhodopsinBovine2.29activatedunligandedunligandedunligandedNANANAX-RAY2015Blankenship et al. 2015
1274XEERhodopsinNTS1 neurotensin receptorRat2.9activated (partially)Neurotensin (8-13)peptideagonistNANAT4L-IL3X-RAY2015Krumm et al. 2015
1284XESRhodopsinNTS1 neurotensin receptorRat2.6activated (partially)Neurotensin (8-13)peptideagonistNANAT4L-IL3X-RAY2015Krumm et al. 2015
1294XNVRhodopsinP2Y1 receptorHuman2.2inactiveBPTUsmall moleculeantagonistNANAT4L-NT and Rubredoxin-IL3X-RAY2015Zhang et al. 2015
1304XNWRhodopsinP2Y1 receptorHuman2.7inactiveMRS2500small moleculeantagonistNANAT4L-NT and Rubredoxin-IL3X-RAY2015Zhang et al. 2015
1314XT1RhodopsinViral US28 receptorVirus2.89activatedHuman CX3CL1peptideagonistNANanobody (intracellular)NAX-RAY2015Burg et al. 2015
1324XT3RhodopsinViral US28 receptorVirus3.8activatedHuman CX3CL1peptideagonistNANANAX-RAY2015Burg et al. 2015
1334YAYRhodopsinAT1R angiotensin II type 1 receptorHuman2.9inactiveZD7155small moleculeantagonistNANABRIL-NTX-RAY2015Zhang et al. 2015
1344Z34RhodopsinLPA1 receptorHuman3.0inactiveONO-9780307small moleculeantagonistNANABRIL-IL3X-RAY2015Chrencik et al. 2015
1354Z35RhodopsinLPA1 receptorHuman2.9inactiveONO-9780307small moleculeantagonistNANABRIL-IL3X-RAY2015Chrencik et al. 2015
1364Z36RhodopsinLPA1 receptorHuman2.9inactiveONO-3080573small moleculeantagonistNANABRIL-IL3X-RAY2015Chrencik et al. 2015
1374ZJ8RhodopsinOX1 orexin receptorHuman2.75inactiveSuvorexantsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2016Yin et al. 2016
1384ZJCRhodopsinOX1 orexin receptorHuman2.83inactiveSB-674042small moleculeantagonistNANAGlycogen synthase-IL3X-RAY2016Yin et al. 2016
1394ZUDRhodopsinAT1R angiotensin II type 1 receptorHuman2.8inactiveOlmesartansmall moleculeantagonistNANABRIL-NTX-RAY2015Zhang et al. 2015
1404ZWJRhodopsinRhodopsinHuman3.3activatedall-trans-retinalsmall moleculeagonistVisual arrestin-1 (fused)NAT4L-NTX-RAY2015Kang et al. 2015
1415A8ERhodopsinbeta1 adrenergic receptorTurkey2.4inactive7-Methylcyanopindololsmall moleculeinverse agonistNANANAX-RAY2015Sato et al. 2015
1425C1MRhodopsinmu opioid receptorMouse2.1activatedBU75small moleculeagonistNANanobody (intracellular)NAX-RAY2015Huang et al. 2015
1435CXVRhodopsinM1 muscarinic receptorHuman2.7inactiveTiotropiumsmall moleculeinverse agonistNANAT4L-IL3X-RAY2016Thal et al. 2016
1445D5ARhodopsinbeta2 adrenergic receptorHuman2.48inactivecarazololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2016Huang et al. 2016
1455D5BRhodopsinbeta2 adrenergic receptorHuman3.8inactivecarazololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2016Huang et al. 2016
1465D6LRhodopsinbeta2 adrenergic receptorHuman3.2inactiveCarazololsmall moleculeinverse agonistNANAT4LX-RAY2016Ma et al. 2016
1475DGYRhodopsinRhodopsinHuman7.7activatedall-trans-retinalsmall moleculeagonistVisual arrestin-1 (fused)NAT4L-NTX-RAY2016Zhou et al. 2016
1485DHGRhodopsinNociception-orphanin FQ (NOP) receptorHuman3.0inactiveC-35small moleculeantagonistNANABRIL-NTX-RAY2015Miller et al. 2015
1495DHHRhodopsinNociception-orphanin FQ (NOP) receptorHuman3.0inactiveSB-612111small moleculeantagonistNANABRIL-NTX-RAY2015Miller et al. 2015
1505DSGRhodopsinM4 muscarinic receptorHuman2.6inactiveTiotropiumsmall moleculeinverse agonistNANAT4L-IL3X-RAY2016Thal et al. 2016
1515DYSRhodopsinRhodopsinBovine2.3activatedall-trans-retinalsmall moleculeagonistNANANAX-RAY2016Singhal et al. 2016
1525EN0RhodopsinRhodopsinBovine2.81activatedall-trans-retinalsmall moleculeagonistNANANAX-RAY2016Singhal et al. 2016
1535F8URhodopsinbeta1 adrenergic receptorTurkey3.35inactivecyanopindololsmall moleculeantagonistNANANAX-RAY2015Leslie et al. 2015
1545G53RhodopsinA2A adenosine receptorHuman3.4activatedNECAsmall moleculeagonistmini-GsNANAX-RAY2016Carpenter et al. 2016
1555IU4RhodopsinA2A adenosine receptorHuman1.72inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2016Segala et al. 2016
1565IU7RhodopsinA2A adenosine receptorHuman1.9inactive12csmall moleculeantagonistNANABRIL-IL3X-RAY2016Segala et al. 2016
1575IU8RhodopsinA2A adenosine receptorHuman2.0inactive12fsmall moleculeantagonistNANABRIL-IL3X-RAY2016Segala et al. 2016
1585IUARhodopsinA2A adenosine receptorHuman2.2inactive12bsmall moleculeantagonistNANABRIL-IL3X-RAY2016Segala et al. 2016
1595IUBRhodopsinA2A adenosine receptorHuman2.1inactive12xsmall moleculeantagonistNANABRIL-IL3X-RAY2016Segala et al. 2016
1605JQHRhodopsinbeta2 adrenergic receptorHuman3.2inactiveCarazololsmall moleculeinverse agonistNANanobody (intracellular)T4L-NTX-RAY2016Staus et al. 2016
1613SN6Rhodopsinbeta2 adrenergic receptorHuman3.2activatedBI-167107small moleculeagonistGs heterotrimerNanobody (bound to G protein)T4L-NTX-RAY2011Rasmussen et al. 2011b
1623UONRhodopsinM2 muscarinic receptorHuman3.0inactive3-quinuclidinyl-benzilatesmall moleculeantagonistNANAT4L-IL3X-RAY2012Haga et al. 2012
1634OO9GlutamatemGlu5 receptorHuman2.6inactiveMavoglurantsmall moleculeantagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2014Dore et al. 2014
1644OR2GlutamatemGlu1 receptorHuman2.8inactiveFITMsmall moleculeantagonist (negative allosteric modulator)NANABRIL-NTX-RAY2014Wu et al. 2014
1655CGCGlutamatemGlu5 receptorHuman3.1inactiveComp. 14small moleculeantagonist (negative allosteric modulator)NANANAX-RAY2015Christopher et al. 2015
1665CGDGlutamatemGlu5 receptorHuman2.6inactiveComp. 25small moleculeantagonist (negative allosteric modulator)NANANAX-RAY2015Christopher et al. 2015
1675GLHRhodopsinETB endothelin receptorHuman2.8activatedEndothelin-1peptideagonistNANAT4L-IL3X-RAY2016Shihoya et al. 2016
1685GLIRhodopsinETB endothelin receptorHuman2.5inactiveunligandedunligandedunligandedNANAT4L-IL3X-RAY2016Shihoya et al. 2016
1695K2ARhodopsinA2A adenosine receptorHuman2.5inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2016Batyuk et al. 2016
1705K2BRhodopsinA2A adenosine receptorHuman2.5inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2016Batyuk et al. 2016
1715K2CRhodopsinA2A adenosine receptorHuman1.9inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2016Batyuk et al. 2016
1725K2DRhodopsinA2A adenosine receptorHuman1.9inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2016Batyuk et al. 2016
1735TGZRhodopsinCB1 cannabinoid receptorHuman2.8inactiveAM6538small moleculeantagonistNANAFlavodoxin-IL3X-RAY2016Hua et al. 2016
1745V56FrizzledSmoothenedHuman2.9inactiveTC114small moleculeantagonistNANAFlavodoxin-IL3X-RAY2017Zhang et al. 2017
1755V57FrizzledSmoothenedHuman3.0inactiveTC114small moleculeantagonistNANAFlavodoxin-IL3X-RAY2017Zhang et al. 2017
1765VEWSecretinGLP1 glucagon-like peptide receptorHuman2.7inactivePF-06372222small moleculeantagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2017Song et al. 2017
1775VEXSecretinGLP1 glucagon-like peptide receptorHuman3.0inactiveNNC0640small moleculeantagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2017Song et al. 2017
1785XEZSecretinGlucagon receptorHuman3.0inactiveNNC0640small moleculeantagonist (negative allosteric modulator)NAFab (bound to extracellular domain)T4L-IL2X-RAY2017Zhang et al. 2017
1795XF1SecretinGlucagon receptorHuman3.19inactiveNNC0640small moleculeantagonist (negative allosteric modulator)NAFab (bound to extracellular domain)T4L-IL2X-RAY2017Zhang et al. 2017
1805LWERhodopsinCCR9 chemokine receptorHuman2.8inactiveVercirnonsmall moleculeantagonist (allosteric)NANANAX-RAY2016Oswald et al. 2016
1815NDDRhodopsinPAR2 proteinase-activated receptorHuman2.8inactiveAZ8838small moleculeantagonistNANABRIL-IL3X-RAY2017Cheng et al. 2017
1825NDZRhodopsinPAR2 proteinase-activated receptorHuman3.6inactiveAZ3451small moleculeantagonist (allosteric)NANABRIL-IL3X-RAY2017Cheng et al. 2017
1835NJ6RhodopsinPAR2 proteinase-activated receptorHuman4.0inactiveAZ7188small moleculeantagonistNAFab (extracellular)BRIL-IL3X-RAY2017Cheng et al. 2017
1845T04RhodopsinNTS1 neurotensin receptorRat3.3activated (partially)Neurotensin (8-13)peptideagonistNANAT4L-IL3X-RAY2016Krumm et al. 2016
1855T1ARhodopsinCCR2 chemokine receptorHuman2.81inactiveBMS-681 + CCR2-RA-[R]small moleculeantagonist + allosteric antagonistNANAT4L-IL3X-RAY2016Zheng et al. 2016
1865TE3RhodopsinRhodopsinBovine2.7activatedunligandedunligandedunligandedNANANAX-RAY2017Gulati et al. 2017
1875TE5RhodopsinRhodopsinBovine4.01inactive6mrsix-carbon ring retinal chromophoreinverse agonistNANANAX-RAY2017Gulati et al. 2017
1885TVNRhodopsin5-HT2B serotonin receptorHuman2.9inactive or minimally activatedLSDsmall moleculeagonist (biased, beta-arrestin)NANABRIL-IL3X-RAY2017Wacker et al. 2017
1895U09RhodopsinCB1 cannabinoid receptorHuman2.6inactiveTaranabantsmall moleculeinverse agonistNANAPGS-IL3X-RAY2016Shao et al. 2016
1905UENRhodopsinA1 adenosine receptorHuman3.2inactiveDU172small moleculeantagonistNANABRIL-IL3X-RAY2017Glukhova et al. 2017
1915UIGRhodopsinA2A adenosine receptorHuman3.5inactiveComp. 1small moleculeantagonistNANABRIL-IL3X-RAY2017Sun et al. 2017
1925UNFRhodopsinAT2R angiotensin II type 2 receptorHuman2.8active-likeComp. 1small moleculeligandNANABRIL-NTX-RAY2017Zhang et al. 2017
1935UNGRhodopsinAT2R angiotensin II type 2 receptorHuman2.8active-likeComp. 1small moleculeligandNANABRIL-NTX-RAY2017Zhang et al. 2017
1945UNHRhodopsinAT2R angiotensin II type 2 receptorHuman2.9active-likeComp. 2small moleculeligandNANABRIL-NTX-RAY2017Zhang et al. 2017
1955UVIRhodopsinA2A adenosine receptorHuman3.2inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2017Martin-Garcia et al. 2017
1965JTBRhodopsinA2A adenosine receptorHuman2.8inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2017Melnikov et al. 2017
1975TZRRhodopsinFFA1 receptor (GPR40)Human2.2inactive or minimally activatedMK-8666small moleculepartial agonistNANAT4L-IL3X-RAY2017Lu et al. 2017
1985TZYRhodopsinFFA1 receptor (GPR40)Human3.22inactive or minimally activatedMK-8666 + AP8small moleculepartial agonist + full allosteric agonistNANAT4L-IL3X-RAY2017Lu et al. 2017
1995NX2SecretinGLP1 glucagon-like peptide receptorHuman3.7activatedPeptide 5peptideagonistNANABRIL-NTX-RAY2017Rappas et al. 2017
2005KW2RhodopsinFFA1 receptor (GPR40)Human2.76inactive or minimally activatedTAK-875small moleculepartial agonistNANAT4L-IL3X-RAY2018Ho et al. 2018
2015MZJRhodopsinA2A adenosine receptorHuman2.0inactiveTheophyllinesmall moleculeantagonistNANABRIL-IL3X-RAY2017Cheng et al. 2017
2025MZPRhodopsinA2A adenosine receptorHuman2.1inactiveCaffeinesmall moleculeantagonistNANABRIL-IL3X-RAY2017Cheng et al. 2017
2035N2RRhodopsinA2A adenosine receptorHuman2.8inactivePSB36small moleculeantagonistNANABRIL-IL3X-RAY2017Cheng et al. 2017
2045N2SRhodopsinA1 adenosine receptorHuman3.3inactivePSB36small moleculeantagonistNANABRIL-IL3X-RAY2017Cheng et al. 2017
2055NLXRhodopsinA2A adenosine receptorHuman2.14inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2017Weinert et al. 2017
2065NM2RhodopsinA2A adenosine receptorHuman1.95inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2017Weinert et al. 2017
2075NM4RhodopsinA2A adenosine receptorHuman1.7inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2017Weinert et al. 2017
2085O9HRhodopsinC5a1 complement peptide receptorHuman2.7inactiveNDT9513727small moleculeinverse agonistNANANAX-RAY2018Robertson et al. 2018
2095OLGRhodopsinA2A adenosine receptorHuman1.87inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2105OLHRhodopsinA2A adenosine receptorHuman2.6inactiveVipadenantsmall moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2115OLORhodopsinA2A adenosine receptorHuman3.1inactiveTozadenantsmall moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2125OLVRhodopsinA2A adenosine receptorHuman2.0inactiveLUAA47070small moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2135OLZRhodopsinA2A adenosine receptorHuman1.9inactiveCompound 4esmall moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2145OM1RhodopsinA2A adenosine receptorHuman2.1inactiveCompound 4esmall moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2155OM4RhodopsinA2A adenosine receptorHuman2.0inactiveCompound 4esmall moleculeantagonistNANABRIL-IL3X-RAY2018Rucktooa et al. 2018
2165TUDRhodopsin5-HT2B serotonin receptorHuman3.0activatedErgotaminesmall moleculeagonistNAFab (extracellular)BRIL-IL3X-RAY2017Ishchenko et al. 2017
2175UIWRhodopsinCCR5 chemokine receptorHuman2.2inactive5P7-CCL5peptideantagonistNANARubredoxin-IL3X-RAY2017Zheng et al. 2017
2185V54Rhodopsin5-HT1B serotonin receptorHuman3.9inactiveMethiothepinsmall moleculeantagonistNANAOB1 BRIL-IL3X-RAY2018Yin et al. 2018
2195W0PRhodopsinRhodopsinHuman3.01activatedunligandedNANAVisual arrestinNAT4L-NTX-RAY2017Zhou et al. 2017
2205WF6RhodopsinA2A adenosine receptorHuman2.9inactive or minimally activatedUK432097small moleculeagonistNANAT4L-IL3X-RAY2018White et al. 2018
2215WIURhodopsinD4 dopamine receptorHuman1.96inactiveNemonapridesmall moleculeantagonistNANABRIL-IL3X-RAY2017Wacker et al. 2017
2225WIVRhodopsinD4 dopamine receptorHuman2.14inactiveNemonapridesmall moleculeantagonistNANABRIL-IL3X-RAY2017Wacker et al. 2017
2235WKTRhodopsinRhodopsinBovine3.2activatedB-octylglucosidesmall moleculeNAGt peptideNANAX-RAY2017Broecker et al. 2017
2245WQCRhodopsinOX2 orexin receptorHuman1.96inactiveEMPAsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2017Suno et al. 2017
2255WS3RhodopsinOX2 orexin receptorHuman2.3inactiveEMPAsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2017Suno et al. 2017
2265X7DRhodopsinbeta2 adrenergic receptorHuman2.7inactiveCarazolol + Cmpd-15small moleculeantagonist + allosteric antagonist (intracellular)NANAT4L-IL3X-RAY2017Liu et al. 2017
2275X93RhodopsinETB endothelin receptorHuman2.2inactiveK-8794small moleculeantagonistNANAT4L-IL3X-RAY2017Shihoya et al. 2017
2285XPRRhodopsinETB endothelin receptorHuman3.6inactiveBosentansmall moleculeantagonistNANAT4L-IL3X-RAY2017Shihoya et al. 2017
2295XR8RhodopsinCB1 cannabinoid receptorHuman2.95activatedhexahydrocannabinol (AM841)small moleculeagonistNANAFlavodoxin-IL3X-RAY2017Hua et al. 2017
2305XRARhodopsinCB1 cannabinoid receptorHuman2.8activatedtetrahydrocannabinol (AM11542)small moleculeagonistNANAFlavodoxin-IL3X-RAY2017Hua et al. 2017
2315XSZRhodopsinLPA6 receptor Zebrafish3.2inactiveunliganded (acyl chain of crystallization lipid in binding pocket)NANANANAT4L-IL3X-RAY2017Taniguchi et al. 2017
2325ZBHRhodopsinY1 neuropeptide receptorHuman3.0inactiveBMS-193885small moleculeantagonistNANAT4L-IL3X-RAY2018Yang et al. 2018
2335ZBQRhodopsinY1 neuropeptide receptorHuman2.7inactiveUR-MK299small moleculeantagonistNANAT4L-IL3X-RAY2018Yang et al. 2018
2346AQFRhodopsinA2A adenosine receptorHuman2.51inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2018Eddy et al. 2018
2356B73Rhodopsinkappa opioid receptorHuman3.1activeMP1104small moleculeagonistNANanobody (intracellular)NAX-RAY2018Che et al. 2018
2366BQGRhodopsin5-HT2C serotonin receptorHuman3.0activatedErgotaminesmall moleculeagonistNANABRIL-IL3X-RAY2018Peng et al. 2018
2376BQHRhodopsin5-HT2C serotonin receptorHuman2.7inactiveRitanserinsmall moleculeantagonistNANABRIL-IL3X-RAY2018Peng et al. 2018
2386CM4RhodopsinD2 dopamine receptorHuman2.87inactiveRisperidonesmall moleculeinverse agonistNANAT4-IL3X-RAY2018Wang et al. 2018
2396FK6RhodopsinRhodopsinBovine2.36activatedRS01small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2406FK7RhodopsinRhodopsinBovine2.62activatedRS06small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2416FK8RhodopsinRhodopsinBovine2.87activatedRS08small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2426FK9RhodopsinRhodopsinBovine2.63activatedRS09small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2436FKARhodopsinRhodopsinBovine2.7activatedRS11small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2446FKBRhodopsinRhodopsinBovine3.03activatedRS13small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2456FKCRhodopsinRhodopsinBovine2.46activatedRS15small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2466FKDRhodopsinRhodopsinBovine2.49activatedRS16small moleculeagonistNANANAX-RAY2018Mattle et al. 2018
2476FFHGlutamatemGlu5 receptorHuman2.65inactivefenobamsmall moleculeantagonist + allosteric antagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2018Christopher et al. 2018
2486FFIGlutamatemGlu5 receptorHuman2.2inactiveM-MPEPsmall moleculeantagonist + allosteric antagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2018Christopher et al. 2018
2496D32FrizzledSmoothenedXenopus3.75inactiveCyclopaminesmall moleculeantagonistNANABRIL-IL3X-RAY2018Huang et al. 2018
2506D35FrizzledSmoothenedXenopus3.9inactive or minimally activatedCholesterolsmall moleculeagonist (allosteric, bound to extracellular CRD)NANABRIL-IL3X-RAY2018Huang et al. 2018
2515WB2RhodopsinViral US28 receptorVirus3.5activatedCX3CL1.35peptideagonistNANanobody (intracellular)NAX-RAY2018Jude et al. 2018
2525WF5RhodopsinA2A adenosine receptorHuman2.6activated (partially)UK432097small moleculeagonistNANAT4L-IL3X-RAY2018White et al. 2018
2535XJMRhodopsinAT2R angiotensin II type 2 receptorHuman3.2activated[Ser1, Ile8]AngIIpeptideagonistNAFab (extracellular)BRIL-IL3X-RAY2018Asada et al. 2018
2546BD4FrizzledFZD4 frizzled receptorHuman2.4inactiveunligandedNANANANARubredoxin-IL3X-RAY2018Yang et al. 2018
2556DRXRhodopsin5-HT2B serotonin receptorHuman3.1inactive or minimally activatedlisuridesmall moleculeantagonistTBDNATBDX-RAY2018McCorvy et al. 2018
2566DRYRhodopsin5-HT2B serotonin receptorHuman2.92inactive or minimally activatedmethylergonovinesmall moleculeagonistTBDNATBDX-RAY2018McCorvy et al. 2018
2576DRZRhodopsin5-HT2B serotonin receptorHuman3.1inactive or minimally activatedmethysergidesmall moleculepartial agonist (antagonist for wild type receptor)TBDNATBDX-RAY2018McCorvy et al. 2018
2586DS0Rhodopsin5-HT2B serotonin receptorHuman3.19inactive or minimally activatedLY266097small moleculepartial agonist (biased, Gq)TBDNATBDX-RAY2018McCorvy et al. 2018
2596FUFRhodopsinRhodopsinBovine3.12activatedall-trans retinolsmall moleculeagonistmini-GoNATBDX-RAY2018Tsai et al. 2018
2606FJ3SecretinPTH1 parathyroid hormone receptorHuman2.5inactiveparathyroid hormonepeptideagonistNANAGlycogen synthase-IL3X-RAY2018Ehrenmann et al. 2018
2615YC8RhodopsinM2 muscarinic receptorHuman2.5inactiveNMSsmall moleculeantagonistNANABRIL-IL3X-RAY2018Suno et al. 2018
2625ZHPRhodopsinM3 muscarinic receptorRat3.1inactive6o (BS46)small moleculeantagonistNANAT4L-IL3X-RAY2018Liu et al. 2018
2635ZK3RhodopsinM2 muscarinic receptorHuman2.6inactiveQNB (3-Quinuclidinyl benzilate, BZ)small moleculeantagonistNANABRIL-IL3X-RAY2018Suno et al. 2018
2645ZK8RhodopsinM2 muscarinic receptorHuman3.0inactiveNMSsmall moleculeantagonistNANABRIL-IL3X-RAY2018Suno et al. 2018
2655ZKBRhodopsinM2 muscarinic receptorHuman2.95inactiveAF-DX 384small moleculeantagonistNANABRIL-IL3X-RAY2018Suno et al. 2018
2665ZKCRhodopsinM2 muscarinic receptorHuman2.3inactiveNMSsmall moleculeantagonistNANABRIL-IL3X-RAY2018Suno et al. 2018
2675ZTYRhodopsinCB2 cannabinoid receptorHuman2.8inactiveAM10257small moleculeantagonistNANAT4L-IL3X-RAY2019Li et al. 2019
2686A93Rhodopsin5-HT2A serotonin receptorHuman3.0inactiveRisperidonesmall moleculeantagonistNANABRIL-IL3X-RAY2019Kimura et al. 2019
2696A94Rhodopsin5-HT2A serotonin receptorHuman2.9inactiveZotepinesmall moleculeantagonistNANABRIL-IL3X-RAY2019Kimura et al. 2019
2706AKXRhodopsinCCR5 chemokine receptorHuman2.8inactiveComp. 21small moleculeantagonistNANARubredoxin-IL3X-RAY2018Zhu et al. 2018
2716AKYRhodopsinCCR5 chemokine receptorHuman2.8inactiveComp. 34small moleculeantagonistNANARubredoxin-IL3X-RAY2018Zhu et al. 2018
2726DO1RhodopsinAT1R angiotensin II type 1 receptorHuman2.9ActivatedS1I8peptidepartial agonistNANanobody (intracellular)BRIL-IL3 (not visible)X-RAY2019Wingler et al. 2019
2736E59RhodopsinNK1 tachykinin receptor (substance-P receptor)Human3.4inactiveL760735small moleculeantagonistNANAGlycogen synthase-IL3X-RAY2018Yin et al. 2018
2746GPSRhodopsinCCR2 chemokine receptorHuman3.3inactiveMK-0812small moleculeantagonistNANARubredoxin-IL3X-RAY2019Pautsch et al. 2019
2756GPXRhodopsinCCR2 chemokine receptorHuman2.7inactiveMK-0812small moleculeantagonistNANARubredoxin-IL3X-RAY2019Pautsch et al. 2019
2766HLORhodopsinNK1 tachykinin receptor (substance-P receptor)Human2.4inactiveAprepitantsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2019Schoppe et al. 2019
2776HLPRhodopsinNK1 tachykinin receptor (substance-P receptor)Human2.2inactiveNetupitantsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2019Schoppe et al. 2019
2786IBLRhodopsinbeta1 adrenergic receptorTurkey2.7activatedFormoterolsmall moleculeagonistNANanobody (intracellular)Thioredoxin-NTX-RAY2019Warne et al. 2019
2796IGKRhodopsinETB endothelin receptorHuman2.0inactive or minimally activatedEndothelin-3peptideagonistNANAT4L-IL3X-RAY2018Shihoya et al. 2018
2806IGLRhodopsinETB endothelin receptorHuman2.7inactive or minimally activatedIRL1620peptidepartial agonistNANAT4L-IL3X-RAY2018Shihoya et al. 2018
2816J20RhodopsinNK1 tachykinin receptor (substance-P receptor)Human2.7inactiveAprepitantsmall moleculeantagonistNANAT4L-IL3X-RAY2019Chen et al. 2019
2826J21RhodopsinNK1 tachykinin receptor (substance-P receptor)Human3.2inactiveAprepitantsmall moleculeantagonistNANAT4L-IL3X-RAY2019Chen et al. 2019
2836ME2RhodopsinMT1 melatonin receptorHuman2.8inactive or minimally activatedRamelteonsmall moleculeagonistNANAGlycogen synthase-IL3X-RAY2019Stauch et al. 2019
2846ME3RhodopsinMT1 melatonin receptorHuman2.9inactive or minimally activated2-Phenylmelatoninsmall moleculeagonistNANAGlycogen synthase-IL3X-RAY2019Stauch et al. 2019
2856ME4RhodopsinMT1 melatonin receptorHuman3.2inactive or minimally activated2-Iodomelatoninsmall moleculeagonistNANAGlycogen synthase-IL3X-RAY2019Stauch et al. 2019
2866ME5RhodopsinMT1 melatonin receptorHuman3.2inactive or minimally activatedAgomelatinesmall moleculeagonistNANAGlycogen synthase-IL3X-RAY2019Stauch et al. 2019
2876ME6RhodopsinMT2 melatonin receptorHuman2.8inactive or minimally activated2-Phenylmelatoninsmall moleculeagonistNANABRIL-NT and Rubredoxin-IL3X-RAY2019Johansson et al. 2019
2886ME7RhodopsinMT2 melatonin receptorHuman3.2inactive or minimally activated2-Phenylmelatoninsmall moleculeagonistNANABRIL-NT and Rubredoxin-IL3X-RAY2019Johansson et al. 2019
2896ME8RhodopsinMT2 melatonin receptorHuman3.1inactive or minimally activated2-Phenylmelatoninsmall moleculeagonistNANABRIL-NT and Rubredoxin-IL3X-RAY2019Johansson et al. 2019
2906ME9RhodopsinMT2 melatonin receptorHuman3.3inactive or minimally activatedRamelteonsmall moleculeagonistNANABRIL-NT and Rubredoxin-IL3X-RAY2019Johansson et al. 2019
2916MH8RhodopsinA2A adenosine receptorHuman4.2inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2019Martin-Garcia et al. 2019
2926MXTRhodopsinbeta2 adrenergic receptorHuman2.96activatedSalmeterolsmall moleculeagonistNANanobody (intracellular)T4L-NTX-RAY2018Masureel et al. 2018
2945WB1RhodopsinViral US28 receptorVirus3.51activatedunligandedNANANANanobody (intracellular)NAX-RAY2018Jude et al. 2018
2955X33RhodopsinBLT1 leukotriene B4 receptorNA3.7inactiveBIIL260small moleculeinverse agonistNANAT4L-IL3X-RAY2018Hori et al. 2018
2966AK3RhodopsinEP3 prostanoid receptor (prostaglandin E receptor 3)Human2.9active-likeProstaglandin E2small moleculeagonistNANABRIL-IL3 (not visible)X-RAY2018Morimoto et al. 2018
2976D26RhodopsinDP2 prostanoid receptor (prostaglandin D2 receptor 2, CRTH2)Human2.8inactiveFevipiprantsmall moleculeantagonistNANAT4L-IL3X-RAY2018Wang et al. 2018
2986D27RhodopsinDP2 prostanoid receptor (prostaglandin D2 receptor 2, CRTH2)Human2.74inactiveCAY10471small moleculeantagonistNANAT4L-IL3X-RAY2018Wang et al. 2018
2996IIURhodopsinTP prostanoid receptor (thromboxane A2 receptor)Human2.5inactiveRamatrobansmall moleculeantagonistNANABRIL-NT and Rubredoxin-IL3X-RAY2018Fan et al. 2018
3006IIVRhodopsinTP prostanoid receptor (thromboxane A2 receptor)Human3.0inactiveDaltrobansmall moleculeantagonistNANABRIL-NT and Rubredoxin-IL3X-RAY2018Fan et al. 2018
3015ZKQRhodopsinPAF receptorHuman2.9inactiveABT-491small moleculeinverse agonistNANAT4L-IL3X-RAY2018Cao et al. 2018
3025ZKPRhodopsinPAF receptorHuman2.81inactiveSR 27417small moleculeantagonistNANAFlavodoxin-IL3X-RAY2018Cao et al. 2018
3035YHLRhodopsinEP4 prostanoid receptor (prostaglandin E receptor 4)Human4.2inactiveONO-9990614small moleculeantagonistNAFab (extracellular)NAX-RAY2018Toyoda et al. 2018
3045YWYRhodopsinEP4 prostanoid receptor (prostaglandin E receptor 4)Human3.2inactiveONO-AE3-208small moleculeantagonistNAFab (extracellular)NAX-RAY2018Toyoda et al. 2018
3056M9TRhodopsinEP3 prostanoid receptor (prostaglandin E receptor 3)Human2.5active-likeMisoprostol-FAsmall moleculeagonistNANAT4L-IL3X-RAY2018Audet et al. 2018
3112LNLRhodopsinCXCR1 chemokine receptorHuman0.0NAunligandedNANANANANANMR2012Park et al. 2012
3126CMORhodopsinRhodopsinHuman4.5activatedNANANAGi heterotrimerNATBDElectron Microscopy2018Kang et al. 2018
3135VBLRhodopsinApelin receptorHuman2.6inactiveAMG3054peptideagonistNANARubredoxin-IL3X-RAY2017Ma et al. 2017
3145VRARhodopsinA2A adenosine receptorHuman2.35inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2017Broecker et al. 2017
3156D9HRhodopsinA1 adenosine receptorHuman3.6activatedAdenosinesmall moleculeagonistGi heterotrimerNATBDElectron Microscopy2018Draper-Joyce et al. 2018
3166DDERhodopsinmu opioid receptorHuman3.5activatedDAMGOpeptideagonistGi heterotrimerScFv (bound to G protein)NAElectron Microscopy2018Koehl et al. 2018
3176DDFRhodopsinmu opioid receptorHuman3.5activatedDAMGOpeptideagonistGi heterotrimerNANAElectron Microscopy2018Koehl et al. 2018
3186G79Rhodopsin5-HT1B serotonin receptorHuman3.78activatedDonitriptansmall moleculeagonistGo heterotrimerNATBDElectron Microscopy2018Garcia-Nafria et al. 2018
3196GDGRhodopsinA2A adenosine receptorHuman4.11activatedNECAsmall moleculeagonistMini GsNanobody (bound to G protein)TBDElectron Microscopy2018Garcia-Nafria et al. 2018
3206H7JRhodopsinbeta1 adrenergic receptorTurkey2.8activatedIsoprenalinesmall moleculeagonistNANanobody (intracellular)Thioredoxin-NTX-RAY2018Warne et al. 2018
3216H7LRhodopsinbeta1 adrenergic receptorTurkey2.7activatedDobutaminesmall moleculeagonistNANanobody (intracellular)Thioredoxin-NTX-RAY2018Warne et al. 2018
3226H7MRhodopsinbeta1 adrenergic receptorTurkey2.76activatedSalbutamolsmall moleculeagonistNANanobody (intracellular)Thioredoxin-NTX-RAY2018Warne et al. 2018
3236H7NRhodopsinbeta1 adrenergic receptorTurkey2.5activatedXamoterolsmall moleculeagonistNANanobody (intracellular)Thioredoxin-NTX-RAY2018Warne et al. 2018
3246H7ORhodopsinbeta1 adrenergic receptorTurkey2.8activatedCyanopindololsmall moleculeagonistNANanobody (intracellular)Thioredoxin-NTX-RAY2018Warne et al. 2018
3256HLLRhodopsinNK1 tachykinin receptor (substance-P receptor)Human3.27inactiveCP-99,994small moleculeantagonistNANAGlycogen synthase-IL3X-RAY2019Schoppe et al. 2019
3266MEORhodopsinCCR5 chemokine receptorHuman3.9inactiveT-cell surface glycoprotein CD4 + HIV envelope glycoprotein gp160proteinNANANANAElectron Microscopy2018Shaik et al. 2018
3276METRhodopsinCCR5 chemokine receptorHuman4.5inactiveT-cell surface glycoprotein CD4 + HIV envelope glycoprotein gp160proteinNANANANAElectron Microscopy2018Shaik et al. 2018
3286N4BRhodopsinCB1 cannabinoid receptorHuman3.0activatedFUBsmall moleculeagonistGi heterotrimerNATBDElectron Microscopy2019Krishna Kumar et al. 2019
3296OIJRhodopsinM1 muscarinic receptorHuman3.3activatedIperoxosmall moleculeagonistG11 heterotrimerScFv (bound to G protein)NAElectron Microscopy2019Maeda et al. 2019
3306OIKRhodopsinM2 muscarinic receptorHuman3.6activatedIperoxosmall moleculeagonistGo heterotrimerScFv (bound to G protein)NAElectron Microscopy2019Maeda et al. 2019
3316N51GlutamatemGlu5 receptorHuman4.0activatedQuisqualatesmall moleculeagonistNANanobody (bound to extracellular domain)TBDElectron Microscopy2019Koehl et al. 2019
3326N52GlutamatemGlu5 receptorHuman4.0inactiveunligandedNANANANanobody (bound to extracellular domain, not visible)NAElectron Microscopy2019Koehl et al. 2019
3336NIYSecretinCalcitonin receptorHuman3.34activatedsCTpeptideagonistGs heterotrimerNANAElectron Microscopy2019Dal Maso et al. 2019
3345UZ7SecretinCalcitonin receptorHuman4.1activatedsCTpeptideagonistGs heterotrimerNANAElectron Microscopy2019Liang et al. 2017
3356E3YSecretinCalcitonin receptorHuman3.34activatedsCTpeptideagonistGs heterotrimerNanobody (bound to G protein)NAElectron Microscopy2019Liang et al. 2018
3365VAISecretinGLP1 glucagon-like peptide receptorRabbit4.1activatedGLP-1peptideagonistGs heterotrimerNANAElectron Microscopy2017Zhang et al. 2017
3376B3JSecretinGLP1 glucagon-like peptide receptorHuman3.3activatedExendin-P5peptideagonist (biased, G protein)Gs heterotrimerNanobody (bound to G protein)TBDElectron Microscopy2018Liang et al. 2018
3386NBFSecretinPTH1 parathyroid hormone receptorRat3.0activatedLA-PTHpeptideagonistGs heterotrimerNanobody (bound to G protein)TBDElectron Microscopy2019Zhao et al. 2019
3396NBHSecretinPTH1 parathyroid hormone receptorRat3.5activatedLA-PTHpeptideagonistGs heterotrimerNanobody (bound to G protein)TBDElectron Microscopy2019Zhao et al. 2019
3406NBISecretinPTH1 parathyroid hormone receptorRat4.0activatedLA-PTHpeptideagonistGs heterotrimerNanobody (bound to G protein)TBDElectron Microscopy2019Zhao et al. 2019
3416O3CFrizzledSmoothenedMouse2.8activatedSAG21ksmall moleculeagonistNANanobody (intracellular)NAX-RAY2019Deshpande et al. 2019
3426OT0FrizzledSmoothenedHuman3.84activated24,25-epoxycholesterolsmall moleculeagonistGi1 heterotrimerNANAElectron Microscopy2019Qi et al. 2019
3436E67Rhodopsinbeta2 adrenergic receptorHuman3.7activatedBI-167107small moleculeagonistGs peptide (fused)NANAX-RAY2019Liu et al. 2019
3446GT3RhodopsinA2A adenosine receptorHuman2.0inactiveAZD4635small moleculeantagonistNANABRIL-IL3X-RAY2019Borodovsky et al. 2019
3456I9KRhodopsinRhodopsin-1Jumping Spider2.14inactive9-cis-retinalsmall moleculeinverse agonistNANANAX-RAY2019Varma et al. 2019
3466IBBRhodopsinSuccinate receptor 1Rat2.12inactiveunligandedNANANANanobody (intracellular)NAX-RAY2019Haffke et al. 2019
3476K1QRhodopsinETB endothelin receptorHuman2.7inactiveIRL2500small moleculeinverse agonistNANAT4L-IL3X-RAY2019Nagiri et al. 2019
3486KQIRhodopsinCB1 cannabinoid receptorHuman3.24inactive or minimally activated (intermediate)CP55940 + ORG27569small moleculeagonist + negative allosteric modulatorNANAGlycogen synthase-IL3X-RAY2019Shao et al. 2019
3496N48Rhodopsinbeta2 adrenergic receptorHuman3.2activatedBI-167107 + positive allosteric modulatorsmall moleculeagonist + positive allosteric modulatorNANanobody (intracellular)T4L-NTX-RAY2019Liu et al. 2019
3506OFJRhodopsinRhodopsinBovine4.5inactiveNANANANANANAElectron Microscopy2019Zhao et al. 2019
3516OS9RhodopsinNTS1 neurotensin receptorHuman3.0activatedJMV449small moleculeagonistGi1 heterotrimerNANAElectron Microscopy2019Kato et al. 2019
3526OSARhodopsinNTS1 neurotensin receptorHuman3.0activated (partially)JMV449small moleculeagonistGi1 heterotrimerNANAElectron Microscopy2019Kato et al. 2019
3536OY9RhodopsinRhodopsinBovine3.9activatedall-trans-retinalsmall moleculeagonistGt heterotrimerNANAElectron Microscopy2019Gao et al. 2019
3546OYARhodopsinRhodopsinBovine3.3activatedall-trans-retinalsmall moleculeagonistGt heterotrimerNanobody (bound to G protein)NAElectron Microscopy2019Gao et al. 2019
3556QNORhodopsinRhodopsinHuman4.38activatedall-trans-retinalsmall moleculeagonistGi1 heterotrimerFab (bound to G protein)NAElectron Microscopy2019Tsai et al. 2019
3566QZHRhodopsinCCR7 chemokine receptorHuman2.1inactiveCmp2105small moleculeallosteric antagonist (intracellular)NANASialidase A-IL3X-RAY2019Jaeger et al. 2019
3576RNKRhodopsinSuccinate receptor 1Rat1.94inactiveNF-56-EJ40small moleculeantagonistNANanobody (intracellular)NAX-RAY2019Haffke et al. 2019
3586JZHRhodopsinA2A adenosine receptorHuman2.25inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2019Nango et al. 2019
3596RZ4RhodopsinCysLT1 cysteinyl leukotriene receptorHuman2.7inactivepranlukastsmall moleculeantagonistNANABRIL-IL3X-RAY2019Luginina et al. 2019
3606RZ5RhodopsinCysLT1 cysteinyl leukotriene receptorHuman2.53inactivezafirlukastsmall moleculeantagonistNANABRIL-IL3X-RAY2019Luginina et al. 2019
3616KJVSecretinGLP1 glucagon-like peptide receptorHuman2.8inactivePF-06372222small moleculeantagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2019Song et al. 2019
3626KK1SecretinGLP1 glucagon-like peptide receptorHuman2.8inactivePF-06372222small moleculeantagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2019Song et al. 2019
3636KK7SecretinGLP1 glucagon-like peptide receptorHuman3.1inactivePF-06372222small moleculeantagonist (negative allosteric modulator)NANAT4L-IL2X-RAY2019Song et al. 2019
3666PRZRhodopsinbeta2 adrenergic receptorHuman2.8inactivealprenololsmall moleculeantagonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3676PS0Rhodopsinbeta2 adrenergic receptorHuman3.4inactivecarazololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3686PS1Rhodopsinbeta2 adrenergic receptorHuman3.2inactivetimololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3696PS2Rhodopsinbeta2 adrenergic receptorHuman2.4inactivealprenololsmall moleculeantagonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3706PS3Rhodopsinbeta2 adrenergic receptorHuman2.5inactivecarvedilolsmall moleculeinverse agonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3716PS4Rhodopsinbeta2 adrenergic receptorHuman2.6inactiveICI-118551small moleculeinverse agonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3726PS5Rhodopsinbeta2 adrenergic receptorHuman2.9inactivePropranololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3736PS6Rhodopsinbeta2 adrenergic receptorHuman2.7inactiveTimololsmall moleculeinverse agonistNANAT4L-IL3X-RAY2019Ishchenko et al. 2019
3746PS7RhodopsinA2A adenosine receptorHuman1.85inactiveZM-241385small moleculeantagonistNANABRIL-IL3X-RAY2019Ishchenko et al. 2019
3756PS8RhodopsinMT1 melatonin receptorHuman3.3inactive or minimally activated2-Phenylmelatoninsmall moleculeagonistNANAGlycogen synthase-IL3X-RAY2019Ishchenko et al. 2019
3766NI3Rhodopsinbeta2 adrenergic receptorHuman3.8activatedBI-167107small moleculeagonistGs heterotrimer + Beta arrestin 1 (arrestin-2)NANAElectron Microscopy2019Nguyen et al. 2019
3776IQLRhodopsinD4 dopamine receptorMouse3.5inactiveL745870small moleculeantagonistNANABRIL-IL3X-RAY2019Zhou et al. 2019
3786PWCRhodopsinNTS1 neurotensin receptorHuman4.9activatedNeurotensin (9-13)peptideagonistBeta arrestin 1 (arrestin-2)Fab (bound to arrestin)NAElectron Microscopy2019Yin et al. 2019
3796KUWRhodopsinalpha2C adrenergic receptorHuman2.8inactiveRS79948small moleculeantagonistNANAPGS-IL3X-RAY2019Chen et al. 2019
3806KUXRhodopsinalpha2A adrenergic receptorHuman2.7inactiveRS79948small moleculeantagonistNANABRIL-IL3X-RAY2019Qu et al. 2019
3816KUYRhodopsinalpha2A adrenergic receptorHuman3.2inactive or minimally activatedRESsmall moleculepartial agonistNANABRIL-IL3X-RAY2019Qu et al. 2019
3826OL9RhodopsinM5 muscarinic receptorHuman2.54inactiveTiotropiumsmall moleculeinverse agonistNANAT4L-IL3X-RAY2019Vuckovic et al. 2019
3836RZ6RhodopsinCysLT2 cysteinyl leukotriene receptorHuman2.43inactiveONO-2570366small moleculeantagonistNANABRIL-IL3X-RAY2019Gusach et al. 2019
3846RZ7RhodopsinCysLT2 cysteinyl leukotriene receptorHuman2.43inactiveONO-2570366small moleculeantagonistNANABRIL-IL3X-RAY2019Gusach et al. 2019
3856RZ8RhodopsinCysLT2 cysteinyl leukotriene receptorHuman2.7inactiveONO-2080365small moleculeantagonistNANABRIL-IL3X-RAY2019Gusach et al. 2019
3866RZ9RhodopsinCysLT2 cysteinyl leukotriene receptorHuman2.73inactiveONO-2770372small moleculeantagonistNANABRIL-IL3X-RAY2019Gusach et al. 2019
3876PT2Rhodopsindelta opioid receptorHuman2.8activatedKGCHM07peptideagonistNANABRIL-NTX-RAY2019Claff et al. 2019
3886PT3Rhodopsindelta opioid receptorHuman3.3activatedDPI-287small moleculeagonistNANABRIL-NTX-RAY2019Claff et al. 2019
3896TO7RhodopsinOX1 orexin receptorHuman2.26inactiveSuvorexantsmall moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3906TODRhodopsinOX1 orexin receptorHuman2.11inactiveEMPAsmall moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3916TP3RhodopsinOX1 orexin receptorHuman3.04inactiveDaridorexantsmall moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3926TP4RhodopsinOX1 orexin receptorHuman3.01inactiveACT-462206small moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3936TP6RhodopsinOX1 orexin receptorHuman2.34inactiveFilorexantsmall moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3946TPGRhodopsinOX2 orexin receptorHuman2.74inactiveEMPAsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2020Rappas et al. 2020
3956TPJRhodopsinOX2 orexin receptorHuman2.74inactiveSuvorexantsmall moleculeantagonistNANAGlycogen synthase-IL3X-RAY2020Rappas et al. 2020
3966TPNRhodopsinOX2 orexin receptorHuman2.61inactiveHTL6641small moleculeantagonistNANAGlycogen synthase-IL3X-RAY2020Rappas et al. 2020
3976TQ4RhodopsinOX1 orexin receptorHuman2.3inactiveCompound 16small moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3986TQ6RhodopsinOX1 orexin receptorHuman2.55inactiveCompound 14small moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
3996TQ7RhodopsinOX1 orexin receptorHuman2.66inactiveSB-334867small moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
4006TQ9RhodopsinOX1 orexin receptorHuman2.65inactiveSB-408124small moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
4016JODRhodopsinAT2R angiotensin II type 2 receptorHuman3.2activatedAngiotensin IIpeptideagonistNAFab (extracellular)BRIL-NTX-RAY2020Asada et al. 2020
4026TOSRhodopsinOX1 orexin receptorHuman2.13inactiveGSK1059865small moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
4036TOTRhodopsinOX1 orexin receptorHuman2.22inactiveLemborexantsmall moleculeantagonistNANANAX-RAY2020Rappas et al. 2020
Visualized fields:
Row number PDB ID Family Receptor Organism Resolution Putative State
Ligand Ligand chemical class Ligand pharmacological class Signaling partner Fusion protein Antibody Method Year Reference



Acknowledgement. The preparation and maintenance of this webpage is supported by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) under award number R15GM119084. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIGMS or NIH.
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